1553 The effects of long-pulsed alexandrite laser therapy on facial redness and skin microbiota compositions in rosacea: A prospective, multicentre, single-arm clinical trial

Rosacea is a chronic skin disorder characterized by abnormal neurovasculature and inflammation in the central region of face. The efficacy pulsed-dye laser intense pulse light treatments for rosacea have been demonstrated several clinical trials. However, long-pulsed alexandrite (LPAL) therapy alone to relieve facial redness has not yet studied. To evaluate LPAL on assess changes microbiota composition. Subjects with (n=21, mean age: 39.2±11.3 years) were recruited from two medical institutions received monthly (Clarity II™, Lutronic Corp.) 3 months. At each visit, photographs taken, erythema was measured using spectrometer. initial final visits, Dermatology Life Quality Index (DLQI) Skin Sensitivity Questionnaire (SSQ) evaluated. swabs obtained, microbiome composition analyzed 16s rRNA amplicon sequencing. After three treatment sessions, average index, Mexameter®, decreased significantly, 360.0 ± 96.7 at baseline 312.0 94.5 visit (p<0.05). Of 21 subjects, 16 reported greater than 50% improvement after treatment. DLQI SSQ showed significant improvements symptoms. diversity altered particularly representations genera Clostridium, Lawsonella, Bacteroides, Lactobacillus. favorable rosacea, some impacts